LYMPHOID NEOPLASIA FOXO1 is a tumor suppressor in classical Hodgkin lymphoma
نویسندگان
چکیده
1Institute of Physiological Chemistry, University of Ulm, Ulm, Germany; 2Cancer Center of Union Hospital, Tongji Medical College, HuaZhong University of Science and Technology, Wuhan, China; 3Department of Pathology, University of Ulm, Ulm, Germany; 4Department of Orthopaedic Surgery, Tongji Hospital, Tongji Medical College, HuaZhong University of Science and Technology, Wuhan, China; and 5Department of Pathology and Laboratory Medicine, Centre for Lymphoid Cancers and the Centre for Translational and Applied Genomics, Vancouver, BC
منابع مشابه
FOXO1 is a tumor suppressor in classical Hodgkin lymphoma.
The FOXO transcription factors control proliferation and apoptosis in different cell types. Their activity is regulated by posttranslational modifications, mainly by the PI3K-PKB pathway, which controls nuclear export and degradation. We show that FOXO1 is highly expressed in normal germinal center B cells as well as in non-Hodgkin lymphomas, including follicular lymphoma, diffuse large B-cell ...
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The survival of classical Hodgkin lymphoma (cHL) cells depends on activation of NF-κB, JAK/STAT, and IRF4. Whereas these factors typically induce the master regulator of plasma cell (PC) differentiation PRDM1/BLIMP-1, levels of PRDM1 remain low in cHL. FOXO1, playing a critical role in normal B-cell development, acts as a tumor suppressor in cHL, but has never been associated with induction of ...
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1Department of Hematology, Kumamoto University of Medicine, Kumamoto, Japan; 2Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan; 3Department of Cell Pathology, Kumamoto University of Medicine, Kumamoto, Japan; 4Division of Hematopoiesis, Center for AIDS Research, Kumamoto University, Kumamoto, Japan; and 5Graduate School of Frontier Sciences...
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The transcription factor KLF4 may act both as an oncogene and a tumor suppressor in a tissue-depending manner. In Tand pre-B-cell lymphoma, KLF4 was found to act as tumor suppressor. We found the KLF4 promoter methylated in B-cell lymphoma cell lines and in primary cases of B-cell lymphomas, namely, follicular lymphoma, diffuse large B-cell lymphoma, Burkitt lymphoma, and in classic Hodgkin lym...
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تاریخ انتشار 2012